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Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. Biomed Res Int 2015;2015:284154.View abstract. Ashwagandha is a medicinal herb with a long history. A 2012 clinical study with a pilot arm and a therapeutic arm investigated the efficacy of ashwagandha as an adjunct therapy in treating tuberculosis.32 Recently diagnosed pulmonary tuberculosis patients who had yet to take any anti-tuberculor drugs (ATD) were enlisted. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. 1. PLoS.One. It contains several bioactive compounds, including a group of substances known as withanolides. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Med Res 2015 Jan;141:100-6. NK cell activity was measured before a 15-day washout period when no tea was drunk. J Altern Complement Med. View abstract. Available at: Committee on Herbal Medicinal Products (HMPC). Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. J Ethnopharmacol. Dasgupta A, Tso G, Wells A. Indian J Physiol Pharmacol. Begum, V. H. and Sadique, J. Ashwagandha should be avoided during pregnancy and should not be used while breastfeeding. J Altern Complement Med. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. Indian J Exp Biol 1997;35:236-9. 2020;34:1041-1059. In Phase 2, patients took either ATD, ATD plus ashwagandha, or ATD plus the Ayurvedic multi-herb-and-fruit formulation Chyawanprash (Dabur Research Foundation; New Delhi, India). Upton R, ed. Australian Register of Therapeutic Goods (ARTG). Acta Pol.Pharm. J Atten Disord 2010;14:281-91. Parts Used: Roots Uses: Culinary Uses: None Known The following text is meant for informational purposes only. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. The plant, particularly its root powder, has been used for centuries in traditional Indian medicine. It is widely distributed in stony terrain up to an altitude of 1,700m in Mediterranean regions, as well as the Middle East, Africa, India and Pakistan. Therapeutic Research Faculty 2020. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. The information on this site is intended for educational purposes only and is not a substitute for the advice of a qualified healthcare professional. Cent.Nerv.Syst.Agents Med.Chem. Within the family Solanaceae, <i>Withania</i> is a small genus belonging to the Solanoideae subfamily. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. 1985;23(4):177-183. Phytotherapy Research 1991;5:111-114. [1,2] However, no scientifically valid clinical trials support this use. Solanaceae. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Remenapp A, Coyle K, Orange T, et al. Withanolides have been associated with anti-inflammatory and antioxidant effects. Ashwagandha might lower blood pressure. In: Central Council for Research in Unani Medicine. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Indian J Exp Biol. Ashwagandha has been in use as a medicinal plant for thousands of years, especially in traditional Ayurvedic medicine. Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. Int.J.Crude Drug Res. 1996;35(1):95-100. Ashwagandha: MedlinePlus Supplements The treatment groups in the therapeutic study were the same as those in Phase 2 of the pilot study. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Your source for reliable herbal medicine information. I, 2008),16 Unani Pharmacopoeia of India (Vol. 13 Nov 2013: Wadhwa R, Singh R, Gao R, Shah N, Widodo N, et al. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. United States Pharmacopeia Convention. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Int Ayurvedic Med J 2013;1(5):1-7. Ashwagandha, identification and uses of Withania somnifera A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Evid Based Complement Alternat Med. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. LiverTox: Clinical and research information on drug-induced liver injury. The American J Ayurveda Integr Med. Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgand, Asgandh, Asgandha, Ashagandha, Ashvagandha, Ashwaganda, Ashwanga, Asoda, Asundha, Asvagandha, Aswagandha, Avarada, Ayurvedic Ginseng, Cerise d'Hiver, Clustered Wintercherry, Ghoda Asoda, Ginseng Ayurvdique, Ginseng Indien, Hayahvaya, Indian Ginseng, Kanaje Hindi, Kuthmithi, Orovale, Peyette, Physalis somnifera, Samm Al Ferakh, Samm Al Rerakh, Sogade-Beru, Strychnos, Turangi-Ghanda, Vajigandha, Winter Cherry, Withania, Withania somnifera. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. View abstract. Int Ayurvedic Med J 2013;1:1-7. 2012;10(1):48-49. Indian J Physiol Pharmacol. View abstract. Am J Ther 2023;30(1):e80-e83. It is an erect, greyish, subshrub with inconspicuous yellow or greenish flowers followed by small, spherical, orangish-red berries containing yellow, kidney-shaped seeds. Effect of Withania somnifera on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. Panda S, Kar A. Ashwagandha is not recommended for people who are about to have surgery, or for those who have autoimmune or thyroid disorders. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Bhat J, Damle A, Vaishnav PP, Albers R, Joshi M, Banerjee G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Ottawa, Ontario: NHPD. Skinmed. Panda S, Kar A. Semen volume increased significantly in all test groups except the group with below normal sperm motility. The branches grow in a radial pattern from the center stem. 1992;30:169-172. 8-19-2005;334(1):276-287. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. PLoS One 2021;16(9):e0257843. View abstract. Chitre D, Nadkarni S, Jagtap N, et al. Withania somnifera, commonly known as Ashwagandha (winter cherry), is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for more than 3000 years. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. View abstract. 2022 Mar 25;14:e23494. View abstract. 2012;7:e44419. Debnath PK, Chattopadhyay J, Mitra A, et al. Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Withania Somnifera for use in THMP. Molecular insight into the immune up-regulatory properties Sperm concentration increased significantly in all three test groups after treatment. Unlawful to download, store, or distribute content from this site. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Ashwagandha is an evergreen shrub found in parts of India, Africa, and the Middle East. Duplication is encouraged. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. 4, 2009),18 as well as in the currently valid editions of the British Pharmacopoeia (BP 2012),19 Indian Pharmacopoeia (IP 2010),20 and United States Pharmacopeia (USP 36).21, CURRENT AUTHORIZED USES IN COSMETICS, FOODS, AND MEDICINES, In countries where the Ayurvedic system of medicine is officially recognized and practiced (e.g., India, Bangladesh, Bhutan, Malaysia, Nepal, and Sri Lanka), the powdered dried root of ashwagandha is used, as a component of preparations, for treating inflammatory disorders, phthisis (any wasting or atrophic disease, weakness, diseases due to vata dosha), and male impotence.15, In countries where the Unani system of medicine is officially recognized and practiced (e.g., Bangladesh, India, Malaysia, Pakistan, and Sri Lanka), the dried mature root, referred to as asgand, is used as a component of medicinal formulations to treat leucorrhoea, spermatorrhoea, decreased viscosity of semen, sexual debility, lumbago, and arthritis. Water Extract of Ashwagandha Leaves Has Anticancer Sperm motility improved in all three groups but not significantly in the group with below-normal sperm motility. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Cheah KL, Norhayati MN, Husniati Yaacob L, et al., Mukherjee PK, Banerjee S, Biswas S, et al., Nasimi Doost Azgomi R, Zomorrodi A, Nazemyieh H, et al., Speers AB, Cabey KA, Soumyanath A, et al., White PT, Subramanian C, Motiwala HF, et al.. View abstract. Indian J Psychol Med. View abstract. View abstract. Dasgupta A, Peterson A, Wells A, Actor JK. Abstract. To use the sharing features on this page, please enable JavaScript. View abstract. Withania (Withania somnifera) roots and berries contain alkaloids, steroidal lactones, and saponins. The length of these genomes ranged from 154,162 to 154,364 base pairs (bp). Available at. Medicine (Baltimore). Withania somnifera extract. J Ethnopharmacol. Unlike drugs, dietary supplements are not approved by the U.S. Food and Drug Administration (FDA) before they are sold to the public. Anbalagan, K. and Sadique, J. However, many of the studies have had small sample sizes and have used a variety of ashwagandha preparations. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. View abstract. An open-label, prospective, non-randomized, comparative clinical study published in 2013 addressed the potential use of ashwagandha root extract powder (Himalaya Drug Co.; New Delhi, India) for the mitigation of fatigue caused by chemotherapy and for improving quality of life in patients with breast cancer.29 Patients undergoing chemotherapy for breast cancer were assigned alternately into the study group (n=50) or control group (n=50) and assessed for fatigue. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. J Ethnopharmacol 1999;67:27-35. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. Are there interactions with herbs and supplements? Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Ahmad MK, Mahdi AA, Shukla KK, et al. View abstract. Arch Pathol Lab Med 2007;131:1298-303. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Accessed at. Journal of Research in Ayurveda and Siddha 1980;1:247-258. Many clinical trials (studies in people) have looked at the use of ashwagandha for a variety of health conditions. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Fertil Steril 2010;94:989-96. Ashwagandha is an evergreen shrub found in parts of India, Africa, and the Middle East. View abstract. 1992;30(3):169-172. View abstract. Many herbal products intended for oral use are marketed as dietary supplements. Dasgupta A, Peterson A, Wells A, Actor JK. J Ethnopharmacol 1999;64:91-3. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Efficacy of Withania somnifera supplementation on adult's cognition and mood. 1981;19:245-249. Ashwagandha: Health Benefits, Uses, Safety Information, and More - WebMD Kulkarni RR, Patki PS, Jog VP, et al. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Indian J Exp Biol 2000;38:607-9. View abstract. J Obstet Gynaecol Res 2021. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. Mikolai J, Erlandsen A, Murison A, et al. Cosmetic Ingredients and Substances (CosIng) Database. 8-16-1995;95(1-2):189-193. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Sandhu JS, Shah B, Shenov S, Chauhan S, Lavekar GS, Padhi MM. Altern Med Rev 2000;5:334-46. 2020;34(5):1041-1059. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. 1998;60(2):173-178. Dealing with Ashwagandha Plant Diseases: Identification and Treatment Cooley K, Szczurko O, Perri D, et al. Committee on Herbal Medicinal Products (HMPC). Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. A small, uncontrolled study assessed the immunologic effects of ashwagandha.38 Twice a day for 96 hours, five participants consumed 6 mL ashwagandha root liquid extract (grain ethanol and spring water extraction, Gaia Herbs; Brevard, NC) followed by 8 fl oz whole cows milk. Monograph: Ashwagandha. Concerning its use in cosmetic products, the European Commission Health and Consumers Directorate lists several defined W. somnifera ingredients (root powder, root extract, leaf and root extract, and flower extract) for skin-conditioning function (maintains the skin in good condition). Ashwagandha is one of the most revered plants in traditional Ayurvedic medicine in India. 2020;40:825-829. Ireland PJ, Hardy T, Burt AD, Donnelly MC. The rules for making and distributing dietary supplements are less strict than those for drugs. View abstract. View abstract. Its effect on arterial blood pressure in anaesthetized dogs. View abstract. Cancer Lett. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. 2008;9:369-374. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. View abstract. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Basic Identification: Growing to a height of 2-3 feet (0.6 m-0.9m) or more, ashwagandha has dull, light green leaves. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Bell-shaped flowers bloom during the midsummer months, while orange to red berries emerge in the autumn. Yakugaku Zasshi 2008;128(8):1159-1167. 1965;9(3):127-136. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. View abstract. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. 2021 Nov 30;2021:8254344. J Res Ayur Sid 1980;1:370-385. 1965;9:9-15. These supplements typically contain ashwagandha root, leaf, or root/leaf extracts. We encourage you to discuss any decisions about treatment or care with your health care provider. 2019;11(12):e6466. Acta Oncol. Identification of bioactive molecule from Withania Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. Study 2 was a larger, double-blind, crossover study in which 110 subjects (60 male, 40 female [sic]) were randomly assigned to two groups.36 Each group consumed three cups of tea (Natural Care or regular tea) per day for two months. The mention of any product, service, or therapy is not an endorsement by NCCIH. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Metabolite Profiling in Withania somnifera Roots - PubMed Cooley K, Szczurko O, Perri D, et al. In: Zhang ZY, Lu A, DArcy WG. Cancer Lett. Withania somnifera extract. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Yakugaku Zasshi 2008;128:1159-1167. It's one of the most important herbs in Ayurveda, an ancient study of natural healing that's been practiced in India for more than 6,000 years. Phytother Res. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Ashwagandha (Withania somnifera) Brussels, Belgium: European Commission. Phytomedicine 2000;7(6):463-469. Its effects on arterial blood pressure in anaesthetized dogs. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. View abstract. Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. Exploratory study to evaluate tolerability, safety, and activity of ashwagandha (Withania somnifera) in healthy volunteers. J Ethnopharmacol 1999;67:233-39. Fertil Steril 2010;94:989-96. Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. IV. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. 15 July 2011. View abstract. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. A 2012 single-arm, uncontrolled, observational, dose-response study assessed the safety, tolerability, and activity of escalating doses of ashwagandha.33 For 30 days, at 10-day intervals, 18 healthy participants took increasing doses of ashwagandha (8:1 pulverized ashwagandha root extract; source, preparation, and manufacturer not stated) starting with 250 mg in the morning and 500 mg in the evening (750 mg total/day) on days 1-10, 500 mg in the morning and 500 mg in the evening (1000 mg total/day) on days 11-20, and 500 mg in the morning and 750 mg in the evening (1250 mg total/day) on days 21-30. Withanolides have been associated with anti-inflammatory and antioxidant effects. Outcomes were measured at four, eight, and 12 weeks, with the results suggesting that both treatments caused a significant reduction in anxiety, but the ashwagandha group also experienced significant improvement in quality of life, including reduction of stress, improved vitality, motivation, general health, and patient-specific concerns. http://webprod3.hc-sc.gc.ca/lnhpd-bdpsnh/start-debuter.do? View abstract. All rights reserved. A systematic review and meta-analysis of randomized controlled trials. Alternate name (s): Ayurvedic Ginseng, Indian Ginseng, winter cherry, Withania somnifera 1 Legal status: Legal and available over the counter (OTC) in the United States Suggested dose: Dosing varies; may depend on the brand of supplement or reason for use In: Siddha Pharmacopoeia Committee. 2. 2017 Jan;22:96-106. May help reduce stress and anxiety Ashwagandha is perhaps best known for its ability to reduce stress. Indian J Exp Biol. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha Two 2009 double-blind, pilot studies investigated ashwagandha and four other Ayurvedic herbs for their immune-enhancing effect.36 Study 1 included 32 volunteers randomized to two treatment groups of 16 each who consumed three cups daily of Natural Care tea (ashwagandha [0.5%]; licorice [Glycyrrhiza glabra, Fabaceae, 0.5%]; ginger [1.5%]; holy basil [Ocimum tenuiflorum, Lamiaceae, 0.5%]; and cardamom [Elettaria cardmomum, Zingiberaceae, 1.5%]; Hindustan Unilever Research Center; Bangalore, India) or regular tea (Camellia sinensis, Theaceae) for two months. View abstract. Water Extract of Ashwagandha Leaves Has Anticancer - PLOS 2021;270:113766. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Public statement on. Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Bjrnsson HK, Bjrnsson ES, Avula B, et al. American Botanical Council, 6200 Manor Rd, Austin, TX 78723 Some EU companies also are marketing products with food supplement labeling, for example Pukka Organic Ashwagandha vegetarian capsules (Pukka Herbs Ltd.; Bristol, England). 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. Selective killing of cancer cells by leaf extract of Ashwagandha The test groups comprised patients with infertility for more than one year (n=75; 25 with normal semen profile and infertility of unknown etiology, 25 with below-normal semen profile, and 25 with below-normal sperm motility). In: Government of India Ministry of Health and Family Welfare. Nutrients. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. 2004;42:2015-2020. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Monitor your blood pressure closely. 9-1-2010;10(3):238-246. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. J Ethnopharmacol 1991;33:91-5. Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. View abstract. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. Saeed A, Qureshi T, Shafi U. Revisiting the concept and application of the phenomenon of tadbir (detoxification). Phytotherapy Research 1991;5:111-114. Pharmacol Biochem.Behav 2003;75(3):547-555. Ashwagandha has also been promoted for COVID-19, but there is not sufficient high-quality evidence to support its use.

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