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16, 32673285. Forensic Toxicol. For instance, 500 and 750M Ecdy decreased respiration by approximately 21 and 31%, respectively (Figure 3A). We also determined if ecdysterone affected the level of cell death. As of right now, in early 2023, ecdysterone is only commercially available in the form of capsules and powders. Ecdysterone binds to the estrogen receptor-beta, which induces muscle growth and an increase in muscle mass. Hailed as the possessor of Death Star Delts, he became massively popular on his youtube channel by pointing out false advertisements in supplements and drawing attention to steroid users claiming to be natural. Studies have shown over 100x enhanced solubility of Ecdysterone when complexed with cyclodextrins.Many companies will claim that their product is complexed with Hydroxypropyl--Cyclodextrin. 373 ratings. Some vendors will put less turkesterone in each serving to collect more profit. While it is true that everyones body is different, the right amount of ecdysterone to take in order to see visible progress in the gym will depend on your individual physicality, as well as how your body processes anabolic effects. Exclusive week-long sale! For the entire week, we are having a BOGO sale - Buy 1 Get 1 Free, on our trademarked Turk-Plex (formerly known as Complexed To analyze the influence of ecdysterone on cell death, annexin VFITC/PI kit (BD Biosciences, United States) was used, whereas in studies of combined treatments (doxorubicin and ecdysterone) annexin VFITC/7AAD (ThermoFischer, United States) was applied in accordance with the corresponding manufacturers protocols. Same Day Shipping on all orders placed before 1 PM MST. On label, contains 500 mg of ecdysterone per serving. Gorilla Mind Turkesterone promotes weight loss by decreasing lipid or fat absorption in the body and shifting glucose metabolism and fighting insulin resistance. The literature supports a significant increase in water solubility and bioavailability when the Ecdysterone is complexed correctly. Ecdysterone is a hormone found in arthropods, yet is also synthesized by a number of plants to combat insect pests by disrupting their development, molting, and reproduction. Test levels normal (no test suppression), Changes felt during the cycle: Started with 2 capsules per day, started getting better (deeper) sleep and recovery. You may change your alert preferences or opt out at any time. One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy. This is because on a molecular level we are able to encapsulate the Ecdysterone in a compound called Hydroxypropyl--Cyclodextrin which acts as a shell to increase water solubility and support enhanced bioavailability. Amazon.com: Nutriissa Ecdysterone - Natural Anabolic You might consider Natural Maniac Turkesterone 500Mg as an alternative to Gorilla Mind Turkesterone. Ajuga turkestanica extract is standardized to 10% turkesterone, Comes complexed with -Cyclodextrin, likely aiding bioavailability, Ajuga Turkestanica Extract is standardized to 10% turkesterone, Measurement of doses can be trickier with liquid supplements, May not be standardized to 10% turkesterone, Unique blend of three ingredients shown to potentially support muscle growth and testerone production. Might be an elaborate middle school project. The effect of elton, leveton, fitoton and adapton on the work capacity of experimental animals. Nearly every study referenced in this guide has based their findings off of cycles lasting between 8-10 weeks. In addition, its also been found in arthropods insects with an exoskeleton, like the praying mantis to regulate their moulting and reproduction [5]. Synergistic effect of ecdysterone and doxorubicin calculated using Chou-Talalay algorithms (Chou and Talalay, 1984; Chou, 2006). All of our content is written by people with a strong science background, including medical researchers. Its a fascinating and naturally occurring compound typically found in spinach and quinoa, with the purpose of warding off insect pests. For example, doxorubicin-induced autophagy is involved in the development of chemoresistance, and the inhibition of autophagy effectively overcomes doxorubicin resistance in a variety of cancers (Zhou et al., 2019). For MTT experiments, 10,000 cells were planted overnight in each well of a 96-well plate. Images were analyzed by confocal microscope (Olympus, FV3000, Germany). As much as I like Derek, it looks like his reviews are cherry-picked. All the cell lines used in this study (MCF7, MDA-MB-231, MDA-MB-468, DF2 and WI-38) were purchased from ATCC. Gorilla Mind recommends taking one Turkesterone capsule twice a day. Disclaimer: The contents of Testosterone.org are for informational and educational purposes. Front. doi:10.1002/arch.20334, Dinan, L., and Lafont, R. (2006). During numerous controlled experiments, researchers reported seeing an absence of biomarkers for liver or kidney toxicity [9, 13]. A consistent ecdysterone dose between 500mg 1000mg per day is ideal for most athletes and gym enthusiasts to start seeing rapid gains in muscle mass and strength [3]. Founded in 2017, Gorilla Mind sells fitness supplements via an e-commerce website, including pre-workouts, post-workouts, fat burners, and recovery pills. Instead, in our MTT experiments administration of ecdysterone caused the attenuation of cell growth of breast cancer cells starting from the concentration of 250750M. ITS AWESOME. Taking those factors into account, our number one recommendation for a vetted and trusted source to buy ecdysterone from would be Huge Supplements. Gorilla Minds policy lasts 30 days. Phytoecdysteroids: Biological aspects. *p < 0.05; **p < 0.01; n.s. As part of the combined treatment, based on the Combination Index (CI) and Dose Reduction Index (DRI), Ecdy synergized with doxorubicin to induce cell death in several breast cancer cell lines. Ecdysterone Dosage Guide | Bodybuilding, Cycling, and Safety. BONUS: Order one 500mg Turkesterone bottle now, and youll receive another FREE! We also repeated the previously described treatment of several breast cancer cells with combinations of doxorubicin (0.25 or 0.15 M, respectively) and ecdysterone (250, 500, and 750M) followed by immunofluorescence microscopy to detect the release of cytochrome C from the mitochondria upon apoptosis. Ecdysteroids constitute a class of steroid hormones found in arthropods, which regulate their development including molting and reproduction. Statements regarding Testosterone.org products are the opinions of the individuals making them and are not necessarily the same as those of Testosterone.org. The effect of Ecdy on metabolism of different cancer and non-cancer cells should be studied in further details. Ecdysterone synergizes with doxorubicin and 2-DG to induce apoptosis and death of breast cancer cell lines. The 12 Best Ecdysterone Supplements for 2023 - Lift Vault Another popular absoprtion enhancer is bioperine, though I am not sure if this has been tested for efficacy. (2018). Amazon's Choice for "beta ecdysterone". Due to the fact that its a naturally-occurring compound, its been marketed as being safer than synthetic steroids [2]. Turkesterones primary mechanism of action is to increase protein synthesis and nitrogen retention in muscles, which leads to improved muscle growth and increased strength. Therefore, we decided to assess the influence of Ecdy on the energy metabolism of two TNBC cancer cell lines. Customers Experiences with Gorilla Minds Turkesterone. The observed synergistic effect of doxorubicin and ecdysterone likely results from cell death. Although positive ecdysterone-mediated pharmacological influence on organisms is well documented (Lafont and Dinan, 2003), we decided to examine possible pharmacological effects of ecdysterone on proliferation of human breast cancer cell lines of different molecular subtypes. W03.31.0029. Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities. doi:10.1124/pr.58.3.10, Dinan, L. (2001). Values of the median were used for calculation. Cells grown on glass cover slips were fixed with 4% PFA in PBS for 15min and then washed three times in PBS, followed by 60min incubation in permeabilization blocking solution (5% BSA, 0.3% Triton X-100 in PBS) at room temperature. To offer more perspective on what an effective ecdysterone dosage looks like, we can refer to one study conducted in 2006, where three groups of male athletes of similar body composition were monitored for an 8-week training period. About this item. 5, 6. doi:10.1186/s40170-017-0168-x, Lezina, L., Aksenova, V., Ivanova, T., Purmessur, N., Antonov, A. V., Tentler, D., et al. For some compounds, their bioavailability is dramatically impacted by how water soluble they are. This is not accomplished by simply mixing the two ingredients together and shoving them into a capsule. Akad. SeaHorse energy profiling (Energy Phonotype kit) of (A,B) MDA-MB-231 and (C,D) MDA-MB-468 cancer cell lines treated with 0, 250, 500, 750 or 1,000M Ecdy for 48h. OCRoxygen consumption rate (respiration), ECARextracellular acidification rate (glycolysis). Results of the colony-formation assay for (D) MCF7, (E) MDA-MB-231, and (F) MDA-MB-468 treated with indicated concentration of Ecdy. The modulation of cancer-specific metabolic adaptations weakens the malignant cells and widens the therapeutic window for effective treatment of TNBC patients (Lanning et al., 2017; Wang et al., 2020). icon). This is not accomplished by simply mixing the two ingredients together and shoving them into a capsule. It is a phytoecdysteroid containing a 11-hydroxyl group. Interested in learning more about Turkesterone and how it can improve your body? OF and AD participated in MTT assays. J. Mol. Numerous studies have documented oncogenic properties of male steroid hormones and its derivatives on several human organs, including testis, liver, breast, and others (Sirianni et al., 2012; Salerno et al., 2018). *p < 0.05; **p < 0.01. WebEcdysterone (gorilla mind/intelligent elephant) 8 weeks cycle (feb to March end) : B-cyclodextrin ecdysterone 500mg from Gorilla mind/intelligent elephant. Its not recommended that this dose be exceeded, as once again, studies related to how ecdysterone affects humans is still limited. Collectively, our results indicate that ecdysterone can be considered as a new potential adjuvant for genotoxic therapy in treatment of breast cancer patients. J. Endocrinol. 500 mg of ajuga turkestanica extract can contain varying amounts of turkesterone depending on the source, quality, etc. A few months back, I took Gorilla Mind Turkesterone on a recap after the C-word took me away from training for about 2-3 weeks. Cell Death Differ. Mechanistically, it down-regulates the metabolic potential of cancer cells and induces autophagy. FIGURE 7. OS carried out majority of experiments. There are many factors that impact bioavailability. Values of the median were used for calculation. Results were represented as CI (Combination Index) plots and a Table which includes values for CI and DRI (Dose Reduction Index). Nutriissa Turkesterone Natural Anabolic Dietary Supplement Clinically Tested Muscle Accelerator Blend w/ 500mg Turkesterone vs. Ecdysterone. doi:10.20892/j.issn.2095-3941.2019.0210, Wen, F., Yu, J., He, C. J., Zhang, Z. W., and Yang, A. F. (2019). We do not provide legal advice. Gorilla Mind before beginning a new diet or using any supplement. Your email address will not be published. About 25,000 cells were seeded in 12-well plates and incubated with different amounts of 0750M Ecdy for 4days. One of the control groups ingested 200 mg of ecdysterone per day for the 8-week period. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 6, 650658. Your email address will not be published. Whether youre looking to put on muscle mass or lean up, the ideal ecdysterone dose for bodybuilders is found below. On top of that, while reports of increases in muscle mass and stamina are still contested by some researchers, most studies on ecdysterone have shown a remarkable improvement in humans ability to recover from exercise while using it, as well as enhance their quality of sleep [4]. The next day after being planted in Petri dishes or glass cover slips, cells were treated with 01,500M Ecdy for 32h followed by a co-treatment with the same concentrations of Ecdy and 50M chloroquine to block autophagy for 16h. Then cells were subjected to either western-blot or immunofluorescence. An all-natural, powerful muscle-building supplement that helps to increase muscle size, enhance strength, and improve recovery. It provides a number of beneficial pharmacological effects including the anabolic and adaptogenic ones. Slides were mounted using ProLong Gold Antifate Mountant with DAPI (P36931, Invitrogen). With the founder acting as the brand ambassador, the brand has seen a sharp increase in popularity. With thousands of different products by various companies, it can be tough to know where to start looking for a product. In contrast to cancer cells, ecdysterone displayed a significantly less inhibitory impact on proliferation of human non-transformed fibroblasts compared to cancer cells. Cell. In the case of DF2 cells, the combined treatment (doxorubicin + ecdysterone) displayed even a small protection of these cells from doxorubicin (Supplementary Figure S7A). Gorilla Mind Ecdysterone | News & Prices at PricePlow Results are calculated as the mean SEM of three experiments. Results are represented as the mean SD. Absorption in the gastrointestinal tract is contingent on a molecules water-solubility. Lafont, R., and Dinan, L. (2003). Furthermore, since Ecdy enhances the ability to cope with stress and enhances resistance to tiredness (Bthori et al., 2008; Dinan et al., 2009), it seems beneficial to administer it as part of cytotoxic therapy with doxorubicin. This information, including any referenced scientific or clinical research, is made available for educational purposes only. These data clearly demonstrate the ability of ecdysterone to synergize with doxorubicin to down-regulate the proliferation of breast cancer cells. Top subscription boxes right to your door, 1996-2023, Amazon.com, Inc. or its affiliates, Gorilla Mind Turk-Plex (Turkesterone) - Complexed with Hydroxypropyl--Cyclodextrin for Enhanced Bioavailability (500 mg x 60 Capsules). Having researched Gorilla Mind Turkesterone, we believe it is an effective product produced by a reliable company. Ecdysteroids in plants and their pharmacological effects in vertebrates and humans, in Studies in Natural Products Chemistry (New York, NY: Elsevier), 121145. -ecdysterone protects against apoptosis by promoting autophagy in nucleus pulposus cells and ameliorates disc degeneration. In May 2023, Frontiers adopted a new reporting platform to be Counter 5 compliant, in line with industry standards. CI plots were calculated using Chou-Talalay algorithms (CompuSyn software, http://www.combosyn.com/; hou, 2006). (2012). I made the same review 3 weeks ago and they never posted it, I definitely feel a difference on it. In fact, research has shown that gains in muscle mass, stamina, and strength have been found even with particularly low dosages of 30mg per day [1]. Metabolic targeting of breast cancer cells with the 2-deoxy-D-glucose and the mitochondrial bioenergetics inhibitor MDIVI-1. If you want to take Gorilla Mind Turkesterone on an empty stomach, it is best to take the lower dosage range of 500 mg per day. The study concluded that not only were there no adverse effects, but there was also a marked gain among the participants in lean muscle mass and strength [10]. Flow cytometric determination of cell death including apoptosis was carried out by using annexin V-FITC/(PI or 7-AAD) double staining. Waiting for Gorilla Mind Turkesterone to restock? This will either be declared outright in the product description or a certain percentage standardization (90% to 98% is typical) will be stated. Im on HRT so maybe if I was not I may have felt it more. 2-DG is a promising inhibitor of glycolysis, which decreases the energy of the cancer cells thus making chemotherapy and other treatments more effective. I., Volkova, L., Sidorenko, L., and Todorov, I. N. (2002). Peak Performance Labs Nuclear Power Natural Muscle Builder, Ecdysterone dosage is declared by the manufacturer (500 mg per 2 pill serving), Complexed with cyclodextrin to aid absoprtion, Only absorption aid is BioPerine (to be fair, this may be sufficient). Cell Dev. (A) Cell cycle profiles (flow cytometry) of breast cancer cell lines treated with 0, 250, 500 or 750M Ecdy for 48h. Cell cycle analyses are shown for MCF7 (B), MDA-MB-231 (C), and MDA-MB-468 (D) cells. Metabolic reprogramming in triple-negative breast cancer. Below is a table comparing Natural Maniac and Gorilla Mind: Faster working product at a lower dosage. Gorilla Mind on Twitter: " Exclusive week-long sale Its primary focus is developing supplements that improve exercise performance, expanding into developing health-related supplements. Cancer Biol. On the other hand, anecdotal research suggests that taking Turkesterone on an empty stomach may result in nausea, a common side effect of supplements that enhance performance. Required fields are marked *. No use, distribution or reproduction is permitted which does not comply with these terms. Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: Starving tumors. To determine its synergistic effect we calculate the combination Index (CI) and dose reduction index (DRI) using Chou-Talalay algorithms (Chou and Talalay, 1984; Chou, 2006). Doxorubicin: The good, the bad and the ugly effect. The answer is that ecdysterone is not like the anabolic androgenic steroids commonly used in bodybuilding, such as Dianabol or Trenbolone, as it does not cause testosterone levels to plummet after cycling off. Calorie surplus According to some critics, however, the brand appears to care only about performance and insufficiently about overall safety. As ecdysterone possesses anabolic properties in muscle tissue, we were interested to see whether it alters the energy metabolism of the breast cancer cell lines. doi:10.1111/cas.13928, Keywords: ecdysterone, breast cancer, doxorubicin, autophagy, energy metabolism, synergism, doxorubicin, triple negative breast cancer, combination index, dose reduction index, 2-deoxyglucose, extracellular acidification rate, oxygen consumption rate, multiple drug resistance, Citation: Shuvalov O, Fedorova O, Tananykina E, Gnennaya Y, Daks A, Petukhov A and Barlev NA (2020) An Arthropod Hormone, Ecdysterone, Inhibits the Growth of Breast Cancer Cells via Different Mechanisms. School of Medicine, Southern Illinois University Carbondale, United States. In the case of MDA-MB-468 cell line, the same treatment with ecdysterone has led to an inhibition of both the baseline respiration and of glycolysis (Figures 3C,D). Before I start, I like Dereks stim-free pre-workout. While Ecdy significantly affected the cell cycle distribution of MCF7 cells, it had almost no effect on cell cycle of MDA-MB-468 cells. Lacks deals such as buy one get another free. However, beginners are advised to take one pill or 500mg dose per day. Ecdysterone promotes lean mass gains via estrogen receptor-beta (ER) activation, which is notable since ER signaling is involved in the regulation of skeletal muscle growth and regeneration by stimulating anabolic pathways, activating satellite cells, and modulating immune function, via pathways other anabolic compounds dont typically After protein quantification by BCA assay (ThermoFischer, United States), 20ug of Laemli-diluted cell lysates were loaded on 17% SDS-PAGE, run on TRIS-Glycine running buffer, followed by transfer to a nitrocellulose membrane (Bio-RAD, United States). If youre looking for an in-depth guide on ecdysterone dosage, then youve come to the perfect place. Metabolic Potential (MP) is the measure of cells ability to meet the energy demand via respiration and glycolysis. Ecdy can promote autophagy upon the onset of osteoporosis in rats (Tang et al., 2018). Furthermore, it elicited a two-fold increase in cell death of the MDA-MB-468 cells relative to MCF7. They could be legit, but its usually better to buy from a brand or seller with plenty of reviews from other customers.

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